Table 9.

Phenotypes commonly used as therapeutic outcome indicators

	N171-82Q	R6/1	R6/2	YAC 128
Brain atrophy	39 %	22 %	39 %	63 %
Cell loss	20 %	7 %	4 %	58 %
PolyQ aggregates	48 %	40 %	54 %	26 %
Brain weight	5 %	30 %	17 %	37 %
Rotarod test	78 %	66 %	69 %	79 %
Stride abnormalities	22 %	18 %	20 %	32 %
Locomotor impairment	10 %	19 %	32 %	26 %
Grip strength	7 %	4 %	13 %	5 %
Clasping	10 %	40 %	24 %	16 %
Learning deficits	2 %	15 %	13 %	26 %
Premature death	85 %	4 %	70 %	0 %
Body weight loss	71 %	63 %	76 %	12 %

Table 9 demonstrates how frequently a certain phenotype is tested to reveal the therapeutic outcome. This indirectly indicates the detectability and usefulness of a given phenotype in mice as a potent marker of a therapeutic intervention. Note that when a particular phenotype was tested in an individual therapeutic approach several times (e.g., using different methods), it was counted in the table only once. Phenotypes that were frequently selected as therapeutic intervention markers (in more than 50 % of the approaches) are marked in bold