Table 3.

The 41 groups of “phenotypes” identified in polyQ models belonging to “general phenotypes” categories [neuropathological (N), cognitive (C), motor (M) and other (O)]: the number indicates the amount of records that are present for every “phenotype” in the data table

Neuropathological (N)		Other (O)
polyQ protein aggregates	549	Lifespan	69	Hormonal dysregulation	13
Neuronal morphology alterations	145	Organ pathology	54	SHIRPA change	6
Neuronal physiology alterations	138	Body weight change	54	Body temperature alteration	4
Brain morphology alteration	88	polyQ protein aggregates	51	Circadian rhythm alteration	3
Neuronal loss	62	Muscle abnormalities	42	Abnormal urination	2
Glial abnormalities	55	Posture abnormalities	32	Hearing impairment	2
Retinopathy	16	Fertility	19	Diabetes insipidus	1
Abnormal myelination	10	Adipose tissue dysfunction	15	Narcolepsy	1
Sensorimotor gating impairment	10	Metabolism alteration	14	Visual impairment	1
Neurogenesis impairment	8	Diabetes mellitus	13
Autonomous nervous system (ANS) dysfunction	1
Cognitive (C)		Motor (M)
Learning and memory impairment	42	Balance and coordination alterations	111	Tremor	25
Affective function alteration	23	Locomotor impairment	97	Abnormal sensorimotor response	21
		Gait alteration	52	Seizures	11
		Clasping behavior	37	Dyskinesia	7
		Muscle strength impairment	29