Table 1.
Results of oral glucose tolerance testing (75 grams) from case #4, performed 15 hours after receiving 6 mg of dexamethasone. Hyperglycemia was observed despite excellent secretory capacity of the intraportal islet graft, as documented by elevated insulin and C-peptide levels. The patient’s hemoglobin A1c was 5.7% at this time and several weeks later, suggesting that this profound post-prandial hyperglycemia was transient, related to corticosteroid-induced insulin resistance.
| Time (minutes) | Glucose (mg/dL) | Insulin (mU/L) | C-peptide* (ng/mL) |
|---|---|---|---|
| 0 | 100 | 35 | 3.9 |
| 30 | 291 | 71 | |
| 60 | 431 | 107 | |
| 90 | 410 | 210 | |
| 120 | 303 | 179 | 15.3 |
| 150 | 175 | 111 | |
| 180 | 111 | 63 | |
| 210 | 81 | 47 | |
| 240 | 73 | 38 |
*
C-peptide level was assayed at the fasting and 120 minute time points only