Model validation with urine collected from 67 outpatient cannabis smokers initiating cannabis abstinence. Specimen 1 groups are based on urinary creatinine-normalized (CN)-11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) concentrations. Data are %reuse predictions exceeding the upper prediction limits (80, 90, 95 and 99% probabilities) and therefore, are suggestive of new cannabis use. Expected %re-use prediction rates are 10, 5, 2.5 and 0.5%, respectively. Abstinence was closely monitored with daily observed urine specimens, A includes all data; B includes all data after application of Rules 1 and 2 (see text).