Figure 1.

Allegoric representation of main difference between classic theory and data emerging from scientific literature. Since 1985 Wattenberg proposed chemoprevention strategies, including the ones that foresee the above mentioned manipulation of metabolic (according to the belief that they are classified as “bad-phase I” and “good-phase II”) enzyme activities, and Guengerich published a comprehensive review that suggested the “dual bioactivating and detoxifying nature” of each metabolic enzyme regardless of whether belongs to the phase I or II battery. The last theory (Guengerich) seems the correct ones, since the data emerging from scientific literature.