Table 2. Direction and significance (P<0.05) of effect estimates for the Add Health analytic sample, compared with published results for 41 SNPsa.

	N	Of 41 SNPs, the no. in same direction as published resultsb	P-value	No. of SNPs in same direction as published result and P<0.05c	P-value
European American adolescents	5103	35	2.04E-06	18	2.37E-13
African American adolescents	1748	25	0.05	8	6.87E-04
Hispanic American adolescents	1304	30	0.001	3	0.2
Asian American adolescents	439	24	0.07	5	0.04
Meta-analyzed sample, all adolescents	8594	36	3.41E-07	21	4.60E-17

Abbreviation: SNP, single-nucleotide polymorphism.

β effect estimate for SNP–BMI associations.

^aDirection of effect estimates and nominal significance at P<0.05 is compared with direction of effect estimates and nominal significance in published results with European American adults,^{6, 7, 8, 9, 30, 31} for 41 SNPs.

^bThe number of SNPs for which the direction of effect is concordant between published results and results in Add Health adolescent in the combined sample and by race/ethnicity. The P-value reported is one-tailed, based on a binomial draw with null expectation P=0.5.

^cThe number of SNPs for which the P-value for SNP–BMI association in results in Add Health adolescent in the combined sample and by race/ethnicity directionally consistent and significant at P<−0.05. The P-value reported is one-tailed, based on a binomial draw with null expectation P=0.05.