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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Nat Genet. 2012 Jun 24;44(8):928–933. doi: 10.1038/ng.2332

Figure 1. Spectrum of Overgrowth in Patients with Activating PIK3CA Mutations.

Figure 1

Patient C1 showing (A)&(B) Lower extremity overgrowth with a paucity of facial adipose tissue at ages 12 months and 7 years progressing to (C) Massive leg overgrowth with lack of upper body adipose tissue at 37 years old, by which time left above knee amputation had been undertaken. (D) Right foot overgrowth at 35 years old (E) Feet at 35 years showing overgrowth, cutaneous syndactyly of the left foot and rotational deformity of the right foot .(F) and (G). Patient N7 showing his leg status post debulking surgery and massive overgrowth of the left foot, which was partially amputated. (H) and (I) Patient N99 showing more limited overgrowth confined to several rays of the feet. Informed consent to publish photographs was obtained from the identifiable patient in this figure.