Figure 1.

(A) CNS hierarchy with the traditional neuron-centric framework in red and the revised neuron-glia framework including glial interactions in green. (B) Multi-scale framework of the CNS hierarchy including molecular, synaptic, neuronal, and network level including glial cells., modified from Bouteiller et al. (2011) The molecular level is represented with kinetic schema. The synaptic level includes several molecular elements and their spatio-temporal interaction. The neuron level comprises morphologically realistic neuron model with synapses (blue circles) randomly located on dendritic branches surrounded by astrocyte processes (green arcs). The network level takes into account the interaction between neurons and glial cells.