Figure 3.

(A) The increased number of glutamate transporters affects the peak amplitude of AMPAR-mediated current due to uptake of glutamate. (B) Normalized responses of AMPA mediated EPSCs elicited from a single input pulse for cases with no transporters, 50% density and 100% density of astrocytic glutamate transporters. The decay time course of normalized AMPAR currents with 50% density and without any transporters did not show any change. (C) Glutamate uptake by the glial transporters affects the decay time course of NMDA receptor-mediated EPSC. An increase in the density of transporters results in an increase in the rate of uptake thus decreasing the time of decay of NMDA receptor-mediated EPSC. (D) NMDAR-mediated EPSCs with glial glutamate uptake (red), and with both glial and neuronal uptake (blue). The uptake mediated by neuronal transporters (EAAT3) is not significant.