Model	Parameters	Descriptions	Values
Glutamate diffusion: $\text{Glu}\left(r,t,Q,D,\delta \right)=\frac{Q}{4\pi \delta Dt}{e}^{\frac{-r^z}{4Dt}}$	Q	Number of glutamate molecules	3,000
	δ	Cleft height	20 nm
	D	Glutamate diffusion coefficient	0.4 μm2 ms−1
	R	Distance between the release site and the receptors or transporters	0–400 nm
	t	Time	ms
Glutamate uptake rate per transporter: $\frac{d\text{Gluo}}{dt}=k_6\times \text{Na2ToH}\times \text{Glu}-k_{-6}\times \text{Na2ToGH}+k_3\times \text{Glu}\times \text{Na2To}-k_{-3}\times \text{Na2ToG}$	k6, k3 k−6, k−3	Forward rate constants Backward rate constants	6 mM−1 ms−1 0.5 ms−1
Glutamate at receptor after uptake: Glu – ∈tdGluo	N2ToH, N2ToGH, N2To, N2ToG	Intermediate states of the glutamate transporter	Dynamically change during simulation
		Number of glial glutamate transporters	325
		Number of neuronal glutamate transporters	42
AMPAR-mediated current: $I_{\text{AMPA}}=\text{n}{\text{b}}_{\text{AMPA}}\times \left(g_2{\text{O}}_2+g_3{\text{O}}_3+g_4{\text{O}}_4\right)\times \left(V-V_{\text{rev}}\right)$ Robert and Howe (2003)	nbAMPA	Number of AMPA receptors	80
	g2, g3, g4	Unitary channel conductances associated with open states O2, O3, O4 updated during simulation	9,15, 21 pS respectively
	V	Membrane potential	Dynamically changes during simulation
	Vrev	Reversal potential	0 mV
NMDAR-mediated current: $\begin{array}{l}{I}_{\text{NMDA}}={\text{nb}}_{\text{NMDA}}\frac{Io}{1+\left(\frac{M{g}_0^{2+}}{K_0}\right){\text{e}}^{-\delta zF\Psi m/RT}}\\ I_o=g(V-V_{\text{rev}})O(t)\\ g=g_1+\frac{g_z-g_1}{1+e^{\alpha \Psi m}}\end{array}$	nbNMDA	Number of NMDA receptors	20
	IO	current associated with the open conducting state O	Dynamically changes during simulation
	V	Membrane potential	Dynamically changes during simulation
	Vrev	Reversal potential	0.7 mV
	Mg2+	External Mg concentration	1 mM
	α	is the steepness of the voltage-dependent transition from g1 to g2	0.01
	R	molar gas constant	8.31434 J mol-1 K-1
	F	Faraday constant	9.64867.104 C mol-1
	T	absolute temperature	273.15^ K
Synaptic current: Isyn = IAMPA + INMDA	IAMPA	Current through AMPARs	Dynamically changes during simulation
	INMDA	Current through NMDARs	Dynamically changes during simulation
Neuron model please, see Jarsky et al. (2005)	Simulation archive available from http://dendrites.esam.northwestern.edu/