Table 2.
The genotypes and allele distribution of IRGM polymorphisms in case and control groups.
| Polymorphism | PTB n (%) | Control n (%) | OR (95%CI) | P | *OR (95%CI) | P |
|---|---|---|---|---|---|---|
| −1208 A/G (rs4958842) | ||||||
| AA | 20 (13.3) | 14 (9.3) | Ref. | |||
| AG | 130 (86.7) | 136 (90.7) | 1.49 (0.73–3.08) | 0.277 | 1.53 (0.74–3.18) | 0.250 |
| GG | 0 (0.0) | 0 (0.0) | — | — | — | — |
| Alleles | ||||||
| A | 170 (56.7) | 164 (54.7) | ||||
| G | 130 (43.3) | 136 (45.3) | 0.92 (0.67–1.27) | 0.681 | ||
| −1161 C/T (rs4958843) | ||||||
| TT | 77 (51.3) | 9 (6.0) | Ref. | |||
| CT | 73 (48.7) | 141 (94.0) | 0.06 (0.03–0.12) | <0.001 | 0.06 (0.03–0.13) | <0.001 |
| CC | 0 (0.0) | 0 (0.0) | — | — | — | — |
| Alleles | ||||||
| T | 227 (75.7) | 159 (53.0) | ||||
| C | 73 (24.3) | 141 (47.0) | 0.36 (0.26–0.51) | <0.001 | ||
| −947 C/T (rs4958846) | ||||||
| TT | 138 (92.0) | 113 (75.3) | Ref. | |||
| CT | 12 (8.0) | 35 (23.4) | 0.28 (0.14–0.57) | 0.002 | 0.27 (0.13–0.55) | <0.001 |
| CC | 0 (0.0) | 2 (1.3) | — | — | — | — |
| CT + CC | 12 | 37 (24.66) | 0.26 (0.13–0.53) | <0.001 | 0.26 (0.13–0.53) | <0.001 |
| Alleles | ||||||
| T | 288 (96.0) | 261 (87.0) | ||||
| C | 12 (4.0) | 39 (13.0) | 0.27 (0.14–0.54) | <0.001 |
*Adjusted for age and sex.