Figure 4.

Regulation of cytokines involved in the peripheral pain response.

Notes: Cytokine expression was determined using quantitative RT-PCR. HEK or HDF were treated with PRFE using standard conditions. Total RNA was isolated 2 hours following treatment. Levels are expressed as a fold increase or a fold decrease (n = 6, error bars show standard error of the mean, differences for control versus PRFE-treated are P < 0.05).

Abbreviations: HDF, human dermal fibroblasts; HEK, human epidermal keratinocytes; IL, interleukin; NGF-α, nerve growth factor alpha; TNF-α, tumor necrosis factor-alpha; RT-PCR, reverse transcription polymerase chain reaction.