Table 1. Percentage of surviving C13 cells (combination index*) after treatment with different combinations of carboplatin and VE465.
| Carboplatin concentration (µg/ml) | |||||||
|---|---|---|---|---|---|---|---|
| |
3.9 |
7.8 |
15.6 |
31.25 |
62.5 |
125 |
250 |
| Carboplatin + VE−7 |
72% (1.15) |
65% (1.24) |
67% (1.21) |
41% (1.74) |
17% (3.12) |
9% (2.68) |
7% (1.49) |
| Carboplatin + VE−6 |
72% (1.11) |
69% (1.13) |
62% (1.27) |
38% (1.81) |
15% (3.44) |
10% (2.48) |
7% (1.42) |
| Carboplatin + VE−5 | 33% (1.41) | 33% (1.36) | 26% (1.76) | 19% (2.13) | 11% (2.62) | 9% (1.61) | 7% (0.73) |
*
CI (combination index) values greater than 1 indicate synergistic action of the two combined drugs.