Table 1. IC50 values for L-alanosine and 6-TG.
| |
L-alanosine IC50 (μM) |
6TG uM IC50 |
||||
|---|---|---|---|---|---|---|
| 0 μM MTA | 10 μM MTA | Fold change | 0 μM MTA | 10 μM MTA | Fold change | |
|
M28 (MTAP+) |
24.9 |
1085 |
43.6 |
0.33 |
167.1 |
509.0 |
|
M45 (MTAP+) |
117.4 |
1569 |
13.4 |
0.18 |
248.9 |
1419.9 |
|
M54 (MTAP-) |
0.27 |
0.21 |
0.8 |
0.12 |
0.16 |
1.3 |
|
M78 (MTAP+) |
11.4 |
870.2 |
76.3 |
16.3 |
565.7 |
34.7 |
|
M5 (MTAP-) |
11.9 |
17.5 |
1.5 |
0.22 |
0.38 |
1.7 |
|
M53 (MTAP+) |
14.9 |
966.2 |
65.0 |
0.14 |
192.8 |
1368.3 |
| M82 (MTAP+) | 147.5 | 470.9 | 3.2 | 0.56 | 57.5 | 102.1 |