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Published in final edited form as: Gend Med. 2012 Jul 20;9(4):219–231. doi: 10.1016/j.genm.2012.06.003

Histological analysis of kidneys from young (Y) and old (O), female (F) and male (M) F344 rats. Control (C) rats were gonad intact, and some females were ovariectomized (X) with or without estrogen replacement (E), n=6–9, * = p<0.05 vs respective young rat, + = p<0.05 vs intact female of same age. (A) the % of glomeruli showing any degree of injury, (B) Glomerulosclerosis index (GSI) gives a measure of the severity of individual glomerular damage as well as the % of damaged glomeruli, with 0=100% completely normal glomeruli and 4.0 = 100% damage to 100% of glomeruli [15,19], (C) the total number of casts observed in the kidney section, and (D) the tubulointersititial injury score as 0=none, 1=10%, 2=10–25%, 3=25–50%, 4=50–75%, 5=75–100% [19]. Representative images of sections from kidneys from (E) YFC, (F) OFC, (G) YFX, (H) OFX, (I) YFE, (J) OFE, (K) YMC, (L) OMC rats.

Histological analysis of kidneys from young (Y) and old (O), female (F) and male (M) F344 rats. Control (C) rats were gonad intact, and some females were ovariectomized (X) with or without estrogen replacement (E), n=6–9, * = p<0.05 vs respective young rat, + = p<0.05 vs intact female of same age. (A) the % of glomeruli showing any degree of injury, (B) Glomerulosclerosis index (GSI) gives a measure of the severity of individual glomerular damage as well as the % of damaged glomeruli, with 0=100% completely normal glomeruli and 4.0 = 100% damage to 100% of glomeruli [15,19], (C) the total number of casts observed in the kidney section, and (D) the tubulointersititial injury score as 0=none, 1=10%, 2=10–25%, 3=25–50%, 4=50–75%, 5=75–100% [19]. Representative images of sections from kidneys from (E) YFC, (F) OFC, (G) YFX, (H) OFX, (I) YFE, (J) OFE, (K) YMC, (L) OMC rats.