Table 1. Intravitreal implants.
Implant | Active drug | Approved indication for intravitreal use | Resorbable? | Implantable without suture? |
Ganciclovir | Ganciclovir 4.5 mg | Cytomegalovirus (CMV) retinitis | No | No |
Fluocinolone acetonide | Fluocinolone acetonide 0.59 mg | Chronic non-infectious uveitis | No | No |
Fluocinolone acetonide | Fluocinolone acetonide 0.19 mg | USA: application for approval rejected by the FDA (2011) Europe: positive evaluation (2/2012), approval in Austria (4/2012) and the U.K. (5/2012) | No | Yes |
Triamcinolone acetonide | Triamcinolone acetonide 40 mg/mL | Europe: not approved | Yes, | Yes, |
USA: uveitis or intraocular inflammation not responding to topical steroids, temporal arteritis, sympathetic ophthalmia, intraoperative visualization of the vitreous humor | not an implant but a crystalline suspension | injection of the suspension | ||
Dexamethasone | Dexamethasone 700 µg | Macular edema after BRVO and CRVO; inflammation of the posterior segment of the eye (non-infectious uveitis) | Yes | Yes |
BRVO, branch retinal vein occlusion; CRVO, central retinal vein occlusion; FDA, Food and Drug Administration