Skip to main content
. 2012 Sep 4;122(10):3629–3634. doi: 10.1172/JCI60429

Figure 1. Lung morphology and airway ion transport are normal in naive Slc26a9–/– mice.

Figure 1

(A and B) Representative morphology of conducting airways (A) and lung parenchyma (B) in naive wild-type and Slc26a9–/– mice. Sections were stained with H&E. Scale bars: 100 εm. (C–F) Summary of Vte (C), Rte (D), and Isc (E) under basal conditions, and amiloride-sensitive Isc (F) in freshly excised bronchial tissues from wild-type and Slc26a9–/– mice. (G and H) Amiloride-insensitive Isc and effects of CFTRinh-172 and bumetanide in the absence (–cAMP) (G) and presence (+cAMP) (H) of cAMP-mediated stimulation. (I) UTP-induced Isc in the presence of amiloride and cAMP-dependent stimulation. n = 5–13 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001 compared with mice of the same genotype.