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. 2012 Sep 4;122(10):3629–3634. doi: 10.1172/JCI60429

Figure 3. SLC26A9 prevents airway mucus obstruction in the presence of mucin overproduction in Th2-mediated airway disease.

Figure 3

(A) Representative airway morphology in vehicle- and IL-13–treated wild-type and Slc26a9–/– mice. Sections were stained with Alcian blue–PAS to determine the presence of goblet cells and airway mucus. Scale bars: 100 εm. (B–E) Summary of goblet cell densities (B) and epithelial volume density (C) in main axial airways; fraction (%) of mice showing accumulation of airway mucus (D); and mucus volume density in the airway lumen (E) from vehicle-treated and IL-13–treated wild-type and Slc26a9–/– mice. n = 7–11 mice for each group. **P < 0.01, ***P < 0.001 compared with vehicle-treated mice of the same genotype. ‡P < 0.01, §P < 0.001 compared with IL-13–treated wild-type mice.