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. 2012 Sep 4;122(10):3476–3489. doi: 10.1172/JCI60777

Figure 8. Pharmacologic intervention via inhibition of IL-1 signaling facilitates recovery from acute-on-chronic alcoholic liver injury.

Figure 8

WT mice were treated with alcohol diet for 4 weeks and received 3 intragastric gavages of EtOH (5 g/kg) during the last 3 days of alcohol feeding. On day 28, all mice were switched to control diet, and daily treatment with IL-1Ra or saline was initiated. Liver injury was analyzed using serum ALT (A) and H&E staining (B), and steatosis was evaluated by Oil-red-O staining (B). n = 3–5 per time point and treatment. *P < 0.05 vs. baseline. Original magnification, ×200.