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. 2012 Sep 24;122(10):3791–3795. doi: 10.1172/JCI63937

Figure 1. Effects of PRL infusion with daily injection of PBS or Kp on 6-week-old adult female mice.

Figure 1

(A) Estrous cycle profiles of a single representative mouse from control, PRL, and PRL+Kp groups over 28 days. Each stage of the estrous cycle was determined by daily vaginal smears. Lines under each diagram represent daily intraperitoneal injections of Kp or PBS as control in mice treated with PRL. (B) Mean cycle numbers during 21 days. PRL mice (n = 12) had significantly fewer cycles than control (n = 21) and Kp-treated mice (n = 19). ***P < 0.0001. (C) Representative ovarian histological sections from each group. Asterisks indicate corpora lutea, reflecting ovulation rate. (D) Mean number of corpora lutea in both ovaries at the end of the experiment. Analysis revealed a marked decrease in corpora lutea in the PRL group (n = 6) versus the control (n = 8) and PRL+Kp groups (n = 19). ***P < 0.0001.