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. 2012 Sep 10;122(10):3541–3551. doi: 10.1172/JCI64151

Figure 6. miR-338-3p inhibition elicits gene expression changes analogous to those observed in islets of pregnant rats.

Figure 6

(A) Birc5, Foxm1, Cyclin D2, Igf1r, Irs2, Bcl2, Bcl-xl, and Bad expression in islets of pregnant rats at different stages of gestation were measured by qRT-PCR. Results are presented as fold changes compared with nonpregnant rats and represent mean ± SD of 4 rats per group. Rat (B) and human (C) islet cells were transfected with anti–miR-338-3p. Birc5, Igf1r, Irs2, Bcl2, Bcl-xl, and Bad expression were measured by qRT-PCR and compared with the level in cells transfected with a scrambled anti-miR. Data are expressed as fold changes and represent mean ± SD of 4 (B) or 3 (C) independent experiments. *P < 0.05 vs. control, ANOVA.