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. 2012 Sep 4;122(10):3781–3790. doi: 10.1172/JCI64413

Figure 4. Epitope mapping of 3 pathogenic antibodies.

Figure 4

(A) Alignment of DSG3 amino acid sequence 1–232 with C-cadherin, DSG1, DSG2, and DSG4. EC1, EC2, and EC3 subdomains are highlighted with red, blue, and orange boxes, respectively. Peptides recognized by PVA224 are highlighted in blue and pink, peptides recognized by PVB28 in green, and peptides recognized by PVB124 in light blue, red, and green. The reported amino acid residues bound by AK23 (13) are highlighted in yellow. (B) Location of peptides recognized by PVA224, PVB28, PVB124, and AK23 on the structure of C-cadherin ectodomain as determined in ref. 8. Color code is as above. The trans-adhesive interface is indicated by a gray double arrow. The cis-adhesive interfaces are indicated by orange double arrows.