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. 2012 Sep 4;122(10):3490–3503. doi: 10.1172/JCI64906

Figure 7. Gut-derived serotonin inhibits bone formation by regulating FOXO1-CREB interaction.

Figure 7

(A) Representative vertebral section images from 2-month-old mice. Mineralized bone matrix is stained in black by Von Kossa reagent. Original magnification, ×4. (B) Representative 3D images of transverse CT slices of proximal tibia obtained by high-resolution μCT analysis. (C) Osteoblast proliferation expressed as the number of BrdU-stained osteoblasts per trabecular area or as the percentage of total osteoblasts per trabecular area in sections of femurs (n = 6 mice/group). (D and E) Real-time PCR analysis of indicated genes in bones (n = 4 mice/group). Mice were 2 months old. *P < 0.05 versus WT, #P < 0.05 versus Crebob+/–Foxo1ob+/– group by ANOVA.