Skip to main content
. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Dev Biol. 2010 Dec 10;350(2):393–404. doi: 10.1016/j.ydbio.2010.12.007

Fig. 1.

Fig. 1

SOX17 is a marker of the primitive endoderm and its derivatives, the visceral and parietal endoderm of the mouse embryo. SOX17 is first detected in E3.5 embryos at 32–64 cell stage, localizing to GFP expressing cells in PdgfraH2B–GFP/+ embryos, and at E4.5 is found exclusively in the PrE layer. After implantation (E5.5) SOX17 is expressed only in the two PrE derivatives, PE, which exhibits the highest levels of expression, and VE, which exhibits reduced levels of expression towards distal end of the embryo overlying the epiblast. Each horizontal row represents one embryo. All panels depict single optical sections, the lowest panel depicts a 3D-reconstructions of a confocal z-stack. em: embryonic region; ex: extraembryonic region. Pdgfrα-GFP, green; SOX17, red; Hoechst, blue. Scale bar: 20 μm.