Skip to main content
. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Curr Stem Cell Res Ther. 2012 Jan;7(1):78–91. doi: 10.2174/157488812798483403

Fig. 3. Lineage specification within the inner cell mass of the preimplantation mouse embryo.

Fig. 3

Lineage commitment of PrE and EPI cells is thought to occur around the 64-cell stage and is driven by a core-regulatory network of lineage-restricted transcription factors. FGF4 signaling pathway is a major determinant of PrE specification. FGF4 ligand is synthesized by EPI cells whereas FGFR2 is expressed by PrE cells. Activation of ERK signaling is predicted to be necessary for PrE commitment.

HHS Vulnerability Disclosure