Table 3.
Multivariable-adjusted joint effects of COX2 (−765 G>C) genotypes, various risk factors for colorectal neoplasms, and risk for incident, sporadic colorectal adenomas, MAP Study
| Risk Factors | Genotypes
|
|||
|---|---|---|---|---|
| GG
|
GC+CC
|
|||
| No. of cases/controls | OR (95% CI)a | No. of cases/controls | OR (95% CI)a | |
| NSAIDb use | ||||
| No | 89/90 | 1.00 | 45/60 | 0.71 (0.41–1.22) |
| Yes | 19/37 | 0.46 (0.24–0.92) | 9/24 | 0.51 (0.21–1.22) |
| Pinteraction =0.46 | ||||
| Total fat intakec | ||||
| Low | 58/66 | 1.00 | 29/39 | 0.80 (0.41–1.54) |
| High | 50/61 | 0.77 (0.39–1.55) | 25/45 | 0.61 (0.29–1.31) |
| Pinteraction =0.99 | ||||
| Total polyunsaturated fatc | ||||
| Low | 49/65 | 1.00 | 28/43 | 0.84 (0.43-1.64) |
| High | 59/62 | 1.26 (0.65–2.44) | 26/41 | 0.91 (0.43–1.95) |
| Pinteraction =0.76 | ||||
| Total linoleic acidsc | ||||
| Low | 52/64 | 1.00 | 28/45 | 0.77 (0.40–1.49) |
| High | 56/63 | 1.06 (0.55–2.05) | 26/39 | 0.84 (0.40–1.80) |
| Pinteraction =0.59 | ||||
a
OR (odds ratio) and 95% CI (confidence interval) adjusted for age, race, sex, body mass index, smoking, alcohol intake, total energy intake, physical activity, and family history of colorectal cancer in a first-degree relative. Models for dietary fat and fatty acids intake are also adjusted for NSAID use.
b
Nonsteroidal anti-inflammatory drug
c
All dietary fat intakes classified into low and high based on sex-specific median values in controls