Table 4.
Multivariable-adjusted joint effects of COX2 (8473 T>C) genotypes, various risk factors for colorectal neoplasms, and risk for incident, sporadic colorectal adenomas, MAP study
| Risk Factors | Genotypes
|
|||
|---|---|---|---|---|
| TT
|
TC+CC
|
|||
| No. of cases/controls | OR (95% CI)a | No. of cases/controls | OR (95% CI)a | |
| NSAIDb use | ||||
| No | 50/54 | 1.00 | 84/96 | 1.04 (0.61–1.78) |
| Yes | 14/15 | 1.19 (0.49–2.89) | 14/46 | 0.35 (0.16–0.75) |
| Pinteraction =0.03 | ||||
| Total fat intakec | ||||
| Low | 34/39 | 1.00 | 53/66 | 0.92 (0.49–1.75) |
| High | 30/30 | 0.96 (0.41–2.29) | 45/76 | 0.64 (0.30–1.34) |
| Pinteraction =0.49 | ||||
| Total polyunsaturated fatc | ||||
| Low | 28/40 | 1.00 | 49/68 | 1.06 (0.55–2.06) |
| High | 36/29 | 1.83 (0.80–4.18) | 49/74 | 1.01 (0.49–2.08) |
| Pinteraction =0.15 | ||||
| Total linoleic acidsc | ||||
| Low | 31/39 | 1.00 | 49/70 | 0.90 (0.47–1.73) |
| High | 33/30 | 1.34 (0.58–3.06) | 49/72 | 0.89 (0.43–1.83) |
| Pinteraction =0.20 | ||||
a
OR (odds ratio) and 95% CI (confidence interval) adjusted for age, race, sex, body mass index, smoking, alcohol intake, total energy intake, physical activity, and family history of colorectal cancer in a first-degree relative. Models for dietary fat and fatty acids intake are also adjusted for NSAID use.
b
Nonsteroidal anti-inflammatory drug
c
All dietary fat intakes classified into low and high based on sex-specific median values in controls