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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2012 Jul 10;11(9):1936–1947. doi: 10.1158/1535-7163.MCT-12-0146

Figure 4.

Figure 4

Combination of high dose KX-01 with paclitaxel induced regression of established, large MDA-MB-231 tumors. A) MDA-MB-231 tumors were established in NUDE mice (tumor volume ∼300 mm3) before treatments began. Mice (n=5/group) were treated with vehicle, KX-01 (15mg/kg) by oral gavage once/daily, paclitaxel (PAX, 20mg/kg) once/week by IP (arrows), or KX-01+PAX. Tumor volumes were recorded as mm3±SD. *, P<0.05; (One-Way ANOVA followed by Newman-keuls multiple comparison test. B) Paraffin tumor sections from treatment groups were analyzed by immunofluorescence with anti–tubulin antibody conjugated with Alexafluor-488 (green) and imaged with a confocal microscope (60×). White arrows indicate fragmented microtubules in the KX-01+PAX group.