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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2012 Jul 10;11(9):1936–1947. doi: 10.1158/1535-7163.MCT-12-0146

Figure 5.

Figure 5

KX-01 inhibited invasive stellate formation, invasion, and migration of MDA-MB-231 cells in vitro. A) Invasive stellate structures of MDA-MB-231 cells in 3D culture following vehicle or KX-01 treatment were photomicrographed day4. B) MDA-MB-231 cells were incubated with vehicle (VC) or KX-01 (10, 25, 50nmol/L) for 24h and the number of cells invaded was quantified and normalized to cell number and presented as % relative invasion ±SD. *, P<0.05 statistically significant compared to VC. C) Monolayer cultures of MDA-MB-231 cells were gently scratched with a pipette tip to produce a wound. Photographs of cultures were taken immediately after the scratch (0h) and after 24h incubation with vehicle or KX-01 (5, 10, 25nmol/L). Migration is presented as % gap closure ±SD, *, p<0.05, significantly different from VC. Data are representative of three independent experiments.