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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2012 Jul 10;11(9):1936–1947. doi: 10.1158/1535-7163.MCT-12-0146

Figure 6.

Figure 6

Quantification of micrometastasis of MDA-MB-231 tumors in mouse organs. After necropsy, lung, bone marrow (femur) and liver were collected from treatment groups described in Figure 3 [vehicle control (VC), KX-01, PAX, KX-01+PAX (n=5 mice/group)] and genomic DNA isolated. Micrometastases originating from human primary MDA-MB-231 xenografts were detected by quantitative real-time RT-PCR for an α-satellite DNA sequence in the centromere region of human chromosome-17. Test samples (the number of human cells in each mouse tissue sample) were interpolated from a standard curve as described in Materials and Methods. Graphs represent the number of human cells in intact mouse lung (A), bone marrow from one femur (B) and intact mouse liver (C). *, P<0.05, significantly different compared to VC.