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. 2007 Apr-Jun;12(2):115–128. doi: 10.5863/1551-6776-12.2.115

Figure 2.

Figure 2.

Kinetics of enzyme release for Pangestyme CN-20 (□), Pancrelipase 20,000 URL (○), Lipram CR 20 (∇), Creon 20 Minimicrospheres (▪), Pancrease MT 20 (▵), and Ultrase MT 20 (♦). Released lipase activity is expressed as percentage of actual measured lipase activity at baseline. Fresh product samples were agitated in a disintegration apparatus designed to simulate intestinal peristalsis for 60 minutes at 37°C at pH 5.0. Then the pH was adjusted to 6.0 and the test was continued for an additional 60 minutes. Samples were withdrawn every 15 minutes for the determination of the activity of the lipase released from the enteric coating at each time point. Plotted values are the means for all batches tested for each product (n = 4, except n = 5 for Pangestyme CN-20 and n = 2 for Pancrelipase 20,000 URL; Pancrelipase 20,000 URL was withdrawn from the market).