Table 2.
The diagnostic performance of liver SWV and FibroTest in classifying METAVIR fibrosis (F) stages
|
METAVIR |
|||
|---|---|---|---|
| F1vsF2-4 | F1-2vsF3-4 | F1-3vsF4 | |
| |
Liver SWV |
||
| AUC (95% CI) |
0.847(0.779-0.914) |
0.902 (0.835-0.970) |
0.831 (0.723-0.939) |
| SE of AUC |
0.034 |
0.035 |
0.055 |
| Cutoff (m/s) |
1.55 |
1.81 |
1.98 |
| Sensitivity |
74.1% |
90.2% |
88.9% |
| Specificity |
87.0% |
89.5% |
79.8% |
| PPV |
90.9% |
80.4% |
42.1% |
| NPV |
65.6% |
95.0% |
97.8% |
| Concordance |
78.8% |
89.7% |
81.1% |
| Discordance |
21.2% |
10.3% |
18.9% |
| +LR |
5.7 |
8.6 |
4.4 |
| -LR |
0.3 |
0.1 |
0.1 |
| DOR(95% CI) |
19.0(7.1-51.3) |
79.1(22.9-273.8) |
31.6(6.8-147.9) |
| |
FibroTest |
||
| AUC (95% CI) |
0.823(0.748-0.898) |
0.812 (0.735-0.888) |
0.757 (0.648-0.865) |
| SE of AUC | 0.038 | 0.039 | 0.055 |
Concordance = (true positive n + true negative n)/127, and discordance = (false positive n + false negative n)/127; AUC, area under the receiver operating characteristic curve; DOR, diagnostic odds ratio; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; SE, standard error; SWV, shear wave velocity.