Table 4.
Factors associated with false positivity in patients with METAVIR F1, F2 and F3
| Variable |
Non FP |
FP |
OR(95% CI) | Pvalue |
|---|---|---|---|---|
| n = 77 | n = 32 | |||
| Age, year |
50.8(1.4) |
53.4(2.0) |
|
.316 |
| Gender, male/female (n) |
35/42 |
16/16 |
|
.679 |
| BMI, kg/m2 |
24.34(0.37) |
25.37(0.68) |
|
.155 |
| HCV genotype, 1/non-1 (n) |
38/39 |
15/17 |
|
.836 |
| HCV RNA, x 106, copies/mL |
7.14(1.12) |
10.61(3.12) |
|
.194 |
| ALT, IU/L |
83.01(9.40) |
133.88(15.02) |
|
.004 |
| ALT/ULN (n) |
|
|
|
|
| <1x |
24 |
2 |
reference |
|
| ≧1x <2x |
25 |
10 |
4.8(0.9-24.2) |
.057 |
| ≧2x <3x |
16 |
5 |
3.8(0.6-21.7) |
.140 |
| ≧3x |
12 |
15 |
15.0(2.9-76.6) |
.001* |
| ActiTest A score (n) |
|
|
|
. |
| 0.00-0.35 |
31 |
2 |
reference |
|
| 0.36-0.75 |
24 |
13 |
8.4(1.7-40.8) |
.008* |
| 0.76-1.00 |
22 |
17 |
11.9(2.5-57.2) |
.002* |
| Bilirubin, umol/L |
15.76(0.56) |
19.30(1.12) |
|
.002 |
| Cr, umol/L |
70.82(2.82) |
74.14(4.55) |
|
.817 |
| INR |
1.00(0.01) |
1.05(0.02) |
|
.007 |
| Na, meq/L |
137.94(0.28) |
137.81(0.46) |
|
.527 |
| Platelet, x 109/L |
184.21(6.20) |
158.31(9.37) |
|
.025 |
| METAVIR F1/2/3 (n) |
38/32/7 |
8/8/16 |
|
<.001 |
| METAVIR A (n) |
|
|
|
|
| A0 |
28 |
3 |
reference |
|
| A1 |
45 |
15 |
3.1(0.8-11.7) |
.094 |
| A2-3 |
4 |
14 |
32.7(6.4-166.5) |
<.001* |
| Hepatic steatosis S0/1/2/3/4(n) |
10/28/35/3/1 |
5/9/17/1/0 |
|
.903 |
| Liver SWV, m/s |
1.34(0.03) |
2.40(0.11) |
|
<.001 |
| FibroTest, F score | 0.51(0.03) | 0.72(0.04) | <.001 |
Thirty-two patients of the 109 patients with METAVIR F1, F2 and F3 were false positive (32/109, 29%) in liver fibrosis evaluation using acoustic radiation force impulse elastography. False positive case numbers were: 8 (8/46, 17%) (ARFI LSM > 1.55 m/s) in METAVIR F1; 8 (8/40, 25%) (LSM > 1.81 m/s) in F2; 16 (16/23, 70%) (LSM > 1.98 m/s) in F3 stages. Continuous variables were presented as mean (standard error) and examined using the Student’s t-test. Categorical variables were estimated using Fisher's exact test or univariate binary logistic regression*. ALT, serum alanine aminotransferase; ARFI, acoustic radiation force impulse; CI, confidence interval; Cr, serum creatinine; FP, false positivity; INR, international normalized ratio of prothrombin time; LSM, liver stiffness measurement; METAVIR A, activity; METAVIR F, fibrosis; Na, serum sodium; non FP, true positive + true negative + false negative; OR, odds ratio; SWV, shear wave velocity.