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. 2012 Aug 14;12:189. doi: 10.1186/1471-2334-12-189

Table 2.

Detection of 16 respiratory viruses in 126 specimens

Virus
 No. of specimens
 Performance of the GeXP assay
  GeXP + aRVP + a GeXP + RVP - GeXP- RVP + GeXP-aRVP -a Sensitivity % Specificity % PPVa% NPVa%
FluA
 5
 0
 0
 121
 100
 100
 100
 100
sH1N1b
 3
 0
 0
 123
 100
 100
 100
 100
FluB
 1
 0
 0
 125
 100
 100
 100
 100
PIV1
 1
 0
 0
 125
 100
 100
 100
 100
PIV2
 1
 0
 0
 125
 100
 100
 100
 100
PIV3
 21
 3d
 0
 102
 100
 97.14
 87.50
 100
HRVc
 68
 6
 3
 49
 95.77
 89.09
 91.89
 94.23
HMPV
 8
 0
 2
 116
 80.00
 100
 100
 98.31
Adv
 9
 0
 1
 116
 90.00
 100
 100
 99.15
CoV NL63
 1
 0
 0
 125
 100
 100
 100
 100
CoV OC43
 12
 0
 0
 114
 100
 100
 100
 100
CoV 229E
 2
 0
 0
 124
 100
 100
 100
 100
CoV HKU1
 4
 0
 0
 122
 100
 100
 100
 100
RSVAb
 2
 0
 0
 124
 100
 100
 100
 100
RSVBb
 46
 0
 3
 77
 93.88
 100
 100
 96.25
HBoV 15 0 4 107 78.95 100 100 96.40

a The numbers of positive and negative specimens detected by the GeXP assay are indicated as GeXP + and GeXP -, respectively, and the numbers of positive and negative specimens detected by the RVP Fast assay are indicated as RVP + and RVP -, respectively. The sensitivity (True positives, TP), specificity (True negatives, TN), PPV (TP/TP + false positives), and NPV (TN/TN + false negatives) for each target are calculated using the RVP Fast assay as the reference for comparison.

b The RVP Fast assay was able to subtype the FluA and RSV positive specimens.

c The RVP Fast assay was not able to distinguish rhinovirus from enterovirus, so ‘HRV’ positive detected by the RVP Fast assay could be HRV or enterovirus. All of the specimens positive for HRV detected by the GeXP assay were confirmed by sequencing as true positives.

d All of the additional PIV3 detected only by the GeXP assay were confirmed by sequencing as true positives.