Table 6.

Adjusted comparisons of clinical evolution and outcomes of patients with community-acquired pneumonia according to etiologic categories (N° = 390)

Clinical evolution and outcomes	Conventional Bacteria vs. Others††		Conventional Bacteria vs. Atypical Agents††
	OR (95% CI)	P value	O7R (95% CI)	P value
Clinical evolution
Treatment failure	2.3 (0.9–5.8)	0.1	1.5 (0.6–4.2)	0.4
Severe sepsis	3.0 (1.8–5.1)	<0.0001	2.3 (1.2–4.4)	0.01
Septic shock	15.9 (1.8–142.5)	0.01	11.8 (1.3–109.6)	0.03
Hospitalized	4.5 (2.7–7.5)	<0.0001	5.1 (2.8–9.2)	<0.0001
Admission to intensive care unit	27.9 (3.4–227.9)	0.002	19.5 (2.3–164.1)	0.006
Use of mechanical ventilation	6.0 (0.5–76.8)	0.2	4.6 (0.3–61.7)	0.2
Outcomes
Mortality within 30 days	2.2 (0.4–11.6)	0.4	0.8 (0.1–4.7)	0.8
In-hospital mortality*	1.1 (0.2–6.3)	0.9	0.3 (0.04–2.4)	0.3
Readmission within 30 days*	1.4 (0.4–4.9)	0.6	1.7 (0.3–9.2)	0.5
Length of hospital stay*† (days)
Mean (SD)	1.2 (1–1.6)║	0.05	1.2 (0.9–1.7)║	0.2
>3	2.7 (1.3–5.3)	0.005	3.2 (1.2–8.2)	0.02
Return to daily activity†, mean (SD),days	1.0 (0.9–1.2)║	0.6	1.1 (0.9–1.3)║	0.5
Subsequent hospitalization‡	0.7 (0.1–6.5)	0.8	0.8 (0.1–8.7)	0.9

OR = Odds ratio; CI = Confidence interval.

Treatment failure, septic shock, and severe sepsis are defined in text.

^* Only for hospitalized patients.

^†Inhospital deaths are excluded.

^‡ Only for ambulatory patients.

^††Adjusted analyses were performed comparing the clinical evolution and outcomes between Conventional Bacteria vs. the rest of groups, and between Conventional Bacteria vs. Atypical Agents, adjusting for age, sex and comorbidities.

^║For these two continuous dependent variables, the general linear model was used, and due to the non-normal distribution of these variables, a log transformation was performed. Parameter and standard errors were estimated after exponentiation. Therefore, the parameter estimated is the ratio between the length of hospital stay or the length to return to daily activities of Conventional Bacteria vs. the reference group.