Table 4. Frequency of patient reported progression and improvement in English speaking subjects with SPMS from the IMPACT study.

	Progression (%)	Improvement (%)	p-value
Average of MSQLI components (median)	34.9	30.0
SF36 Physical Components	37.3	32.2	0.91
SF36 Mental Components	43.2	25.4	0.04*
Modified Fatigue Impact Scale (MFIS)	36.2	39.4	0.95
MOS Pain Effects Scale (PES)	34.4	31.2	0.95
Sexual Satisfaction Scale (SSS)	29.5	18.2	0.38
Bladder Control Scale (BLCS)	37.6	21.6	0.04*
Bowel Control Scale (BWCS)	29.3	20.3	0.38
Perceived Deficits Questionnaire (PDQ)	34.9	34.9	1
Impact of Visual Impairment Scale (IVIS)	14.8	14.8	1
Mental Health Inventory (MHI)	38.1	31.7	0.78
Modified MOS Social Support Survey (MSSS)	32.5	30.0	0.95

Note: P values have been adjusted for multiple comparisons.