Table 3. Studies evaluating the association between statin use and risk of advanced prostate cancer.

Study	RR	95% CI	Advanced PCa cases	Definition of “advanced PCa”‡
Platz et al., 2006 [10] *	0.51	0.30–0.86	316	Regionally invasive, metastatic, or fatal: stage T3b or worse, N1, M1, or death from PC
Flick et al., 2007 [8] *	0.8	0.53–1.19	131	Surveillance, Epidemiology and End Results (SEER) staging system, stage II–IV (regional) or VII (distant)
Murtola et al., 2007 [14] †	0.75	0.62–0.91	3,700	Advanced PC; not further defined
Boudreau et al., 2008 [25] *	1.22	0.85–1.75	458	Advanced stage cancer defined as regional or distant stage
Agalliu et al., 2008 [37] †	0.73	0.48–1.10	181	Advanced PC; not further defined
Murtola et al., 2010 [5] *	0.93	0.54–1.58	133	Men with stage T3N0/XM0/X, T4N0/XM0/X, T1-4N1M0 or T1-4N0-1M1 tumors combined
Jacobs et al., 2011 [38] *	0.81	0.61–1.08	317	American Joint Committee on cancer stage III or IV, or fatal PC of unknown stage at diagnosis

RR, Relative risk; CI, Confidence interval; PCa, Prostate cancer.

^*Cohort studies;

^†Case-control studies;

^‡Definition of advanced prostate cancer was taken from original research articles.