Table 1. Hemodynamics and cardiac function in mice.

	Wt	db/db	APS+db/db	MHC- PPARα	APS+MHC− PPARα
HR (bpm)	649±27	585±40	626±32	525±38	638±35
LVPWd (mm)	0.68±0.01	0.82±0.03*	0.72±0.03#	0.87±0.03*	0.73±0.02†
IVSd (mm)	0.70±0.01	0.84±0.04*	0.73±0.02#	0.85±0.04*	0.72±0.02†
LVIDd (mm)	3.2±0.02	3.6±0.04*	3.3±0.03#	3.7±0.04*	3.3±0.03†
LVPWs (mm)	1.10±0.06	1.42±0.02*	1.12±0.06#	1.45±0.03*	1.11±0.08†
IVSs (mm)	1.13±0.07	1.50±0.04*	1.16±0.03#	1.51±0.05*	1.14±0.04†
LVIDs (mm)	1.41±0.05	2.48±0.16*	1.64±0.10#	2.52±0.27*	1.63±0.09†

Values are mean±S.E.M. n = 8 each group.

^*p<0.05 vs. wide type (Wt) mice;

^#p<0.05 vs. untreated db/db mice;

^†P<0.05 vs. untreated MHC-PPARα mice.

HR, heart rate; LVPWd/s, left ventricular posterior wall thickness at diastole or systole; IVSd/s, interventricular septal wall thickness at diastole or systole; LVIDd/s, left ventricular internal diameter at diastole or systole.