Figure 4. O₂ consumption (VO₂) has been analyzed every 16 min for 6 consecutive days in DIO mice treated with HIF-1α ASO, control ASO or observed untreated.

Shaded areas represent the 12 hr dark phase (DP) and unshaded areas represent the 12 hr light phase (LP). VO₂ in HIF-1α ASO treated mice significantly exceeded VO₂ in mice treated with control ASO and untreated mice, p<0.001. VO₂ during the dark phase significantly exceeded those during the light phase, p<0.001.