Table 3.
Characteristicsa of 2070 Cardiovascular Disease-Free Longitudinal Assessment of Bariatric Surgery-2 Participants According to 10-Year Coronary Heart Disease and Lifetime Cardiovascular Disease Predicted Risk Strata
| Low 10-year coronary heart disease predicted risk (total) (n=1314) | Low 10-year coronary heart disease/low lifetime cardiovascular disease predicted risk (n= 321) | Low 10-year coronary heart disease/high lifetime cardiovascular disease predicted risk (n=993) | High 10-year Coronary heart disease predicted risk (n=756) | Pb | Pc | Pd | |
|---|---|---|---|---|---|---|---|
| White | 86.2 (1.0%) | 88.4 (1.8%) | 85.4 (1.1%) | 85.1 (1.3%) | 0.80 | 0.98 | 0.40 |
| Women | 86.3 (1.0%) | 87.2 (1.9%) | 86.0 (1.1%) | 70.2 (1.7%) | <.001 | <.001 | 0.58 |
| Age, years | 41 (34,50) | 37 (31,44) | 43 (35,52) | 50 (42,57) | <.001 | <.001 | <.001 |
| Body mass index, kg/m2 | 45.6 (42.0,50.7) | 45.4 (42.0,50.6) | 45.6 (42.0,50.8) | 46.4 (41.5,52.4) | 0.18 | 0.22 | 0.93 |
| Waist circumference, cme | 127.9 (119.0,138.1) | 127.4 (118.8,138.1) | 128.0 (119.0138.1) | 136.1 (125.0,147.0) | <.001 | <.001 | 0.55 |
| Diabetes mellitus | - | - | - | 89.4 (1.1%) | - | - | - |
| Smoker | 13.2 (0.9%) | - | 17.4 (1.2%) | 12.7 (1.2%) | 0.76 | <.01 | <.001 |
|
| |||||||
| Hypertension | 45.8 (1.4%) | 11.8 (1.8%) | 56.8 (1.6%) | 77.9 (1.5%) | <.001 | <.001 | <.001 |
| Systolic blood pressure, mm/Hg | 128 (120,138) | 123 (116,129) | 130 (121,141) | 131 (122,142) | <.001 | 0.24 | <.001 |
| Diastolic blood pressure, mm/Hg | 80 (74,86) | 78 (73,83) | 81 (75,88) | 78 (71,85) | <.001 | <.001 | <.001 |
| Sleep apnea | 44.3 (1.4%) | 39.9 (2.7%) | 45.7 (1.6%) | 62.0 (1.8%) | <.001 | <.001 | 0.07 |
| High-sensitivity C-reactive protein, mg/Lf | 7.5 (4.2,13.7) | 8.0 (4.3,14.1) | 7.4 (4.2,13.6) | 7.0 (3.7,13.1) | <.01 | 0.02 | 0.50 |
| Anti-hypertensive medications | 37.4 (1.3%) | - | 49.5 (1.6%) | 73.7 (1.6%) | <.001 | <.001 | <.001 |
| Lipid-lowering medications | 12.7 (0.9%) | - | 16.8 (1.2%) | 47.4 (1.8%) | <.001 | <.001 | <.001 |
| Total cholesterol, mg/dL | 188 (164,212) | 170 (153,185) | 198 (170,220) | 181 (153.5,210) | <.001 | <.001 | <.001 |
| Total cholesterol ≥ 200 mg/dL | 36.5 (1.3%) | 0.0 (0.0) | 48.3 (1.6%) | 31.5 (1.7%) | 0.02 | <.001 | <.001 |
|
| |||||||
| Low density lipoprotein cholesterol, mg/dL | 113.5 (93,134) | 99 (84,114) | 120 (97,141) | 102 (78,127) | <.001 | <.001 | <.001 |
| Low density lipoprotein cholesterol ≥ 100 mg/dL | 66.2 (1.3%) | 49.5 (2.8%) | 71.6 (1.4%) | 52.8 (1.8%) | <.001 | <.001 | <.001 |
| High density lipoprotein cholesterol, mg/dL | 44 (38,53) | 43 (38,51) | 45 (38,53) | 41 (35,48) | <.001 | <.001 | 0.40 |
| Low high density lipoprotein cholesterol, mg/dLg | 62.3 (1.3%) | 64.5 (2.7%) | 61.6 (1.5%) | 72.6 (1.6%) | <.001 | <.001 | 0.36 |
| Non-high density lipoprotein cholesterol, mg/dL | 141 (119,164) | 124 (106,139) | 150 (124,172) | 137.5 (110,166) | 0.03 | <.001 | <.001 |
| Non-high density lipoprotein cholesterol ≥ 130 mg/dL | 62.6 (1.3%) | 40.8 (2.7%) | 69.6 (1.5%) | 57.1 (1.8%) | 0.02 | <.001 | <.001 |
| Triglycerides, mg/dL | 129 (94,174) | 102 (80,142) | 135 (100,182) | 162 (116,227) | <.001 | <.001 | <.001 |
| Triglycerides ≥ 150 mg/dL | 35.2 (1.3%) | 21.2 (2.3%) | 39.8 (1.6%) | 56.0 (1.8%) | <.001 | <.001 | <.001 |
10-year Adult Treatment Panel-III hard coronary heart disease risk, with “low” defined as <10% and absence of diabetes mellitus.
a
Values are median (interquartile range) or percentage (standard error),
b
low 10-year vs. high 10-year,
c
low 10-year/high lifetime vs. high 10-year,
d
low 10-year/low lifetime vs. low 10-year/high lifetime,
e
waist circumference missing=95,
f
high-sensitivity C-reactive protein missing=3,
g
Low high density lipoprotein cholesterol <40 mg/dl in men and <50 mg/dl in women