Table 2.
Transepithelial transport of anti-ICAM nanocarriers.
| Total NCs associated/cell |
Intracellular NCs/cell |
NCs transported /cell |
% Transported |
Papp (cm/s × 10−8) |
||
|---|---|---|---|---|---|---|
| − TNF-α | ||||||
| 3h | 873.9 ± 138.4 | 546.2 ± 123.0 | 282.2 ± 37.5 | 44.6 ± 5.9 | 13.2 ± 0.3 | |
| 24 h | 2798.1 ± 172.7 | 1587.6 ± 218.4 | 715.3 ± 34.7 | 41.2 ± 1.9 | 2.1 ± 0.5 | |
| + TNF-α | ||||||
| 3h | 1331.2 ± 232.5 | 985.1 ± 198.1 | 346.1 ± 54.3 | 27.0 ± 3.4 | 7.2 ± 1.1 | |
| 24 h | 2768.1 ± 745.2 | 2244.6 ± 734.3 | 523.5 ± 20.0 | 30.2 ± 6.7 | 1.4 ± 0.1 | |
NCs = nanocarriers; Total NCs associated/cell = NCs in the cell fraction/number of cell + NCs transported/number of cells; % Transported = 100 × (NCs transported / Total NCs associated); Papp = apparent permeability coefficient (cm/s). See Methods for further description of these parameters. Data are shown as means ± S.E.M. (n = 4 wells).