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J-domain proteins recruit client proteins, dock to NBD of DnaK, and catalyze ATP hydrolysis. This converts DnaK from the ATP bound low affinity conformation to the ADP bound conformation with high affinity for client proteins. Nucleotide exchange factors (NEFs), such as GrpE, trigger ADP release. Binding of ATP completes the catalytic cycle by causing release of client protein and co-chaperones.
