Table 2.
List of RBPs involved in translation and implicated in neurological diseases.
| RBP | Function | Disease | Reference |
|---|---|---|---|
| FMRP | Repressor | FXS | Darnell et al. (2011) |
| hnRNP A2/B1 | Activator | ALS, FTLD | Kwon et al. (1999) |
| hnRNP C | Activator | AD | Lee et al. (2010) |
| IGHMBP2 | Regulator | SMA | Grohmann et al. (2001), de Planell-Saguer et al. (2009) |
| Musashi | Repressor | AD | Okano et al. (2002), Perry et al. (2012) |
| SMN | Putative repressor | SMA | Piazzon et al. (2008) |
| TDP-43 | Repressor | ALS, FTLD | Lagier-Tourenne et al. (2010) |
AD, Alzheimer’s disease; ALS, Amyotrophic lateral sclerosis; FTLD, Frontotemporal lobar dementia; FXS, Fragile X syndrome; SMA, Spinal muscular atrophy.