Figure 2.

Increased locomotor activity of PACAP KO mice in the open field test. (A) Distance traveled in the open field test was significantly increased in the PAPAC KO mice compared with wild-type mice. Counts of vertical activity (B), time spent in the center of the compartment (C), counts of stereotypic behavior (D), and resting time (E) were shown. (F) There were no significant differences in the distance traveled in the home cage between WT and KO mice. Data are presented as means ± SEM for the indicated numbers of animals. The p-values indicate genotype effect in two-way repeated measures ANOVA.