Figure 3.

Abnormal anxiety-like and slightly decreased depression-like behaviors in PACAP knockout mice. (A–D) Light/dark transition test: the distance traveled in the light/dark compartments (A), time spent in the light compartment (B), number of light/dark transitions (C), and latency to enter the light compartment (D) were shown. (E–H) Elevated plus maze: the number of arm entries (E), percentage of entries into the open arms (F), distance traveled (G), and percentage of time spent on the open arms (H) were shown. (I,J) Porsolt forced swim test: the percentage of immobility time for day 1 and day 2 (I) and distance traveled for day 1 and day 2 (J) were shown. Data are presented as means ± SEM for the indicated numbers of animals. The p-values indicate the genotype effects in one-way ANOVA (A–H) and two-way repeated measures ANOVA (I,J).