Table 1.
Characteristics of trials
| Overall Trials |
Number of Trials Excluding Recipients ≥65 years (%) |
p- value |
Overall Patients |
Number of Patients in Trials Excluding Recipients ≥65 years (%) |
p-value, weighted by number pts enrolled |
||
|---|---|---|---|---|---|---|---|
| Overall | 573 | 90 (16) | 87,222 | 11,653 (13) | |||
| Era of Publication (%) | |||||||
| 1999 – 2002 | 212 | 34 (16) | 0.98 | 34,745 | 3,873 (11) | <0.01 | |
| 2003 – 2005 | 198 | 31 (16) | 28,780 | 4,470 (16) | |||
| 2006 – 2008 | 163 | 25 (15) | 23,697 | 3,310 (14) | |||
|
Number of Patients Enrolled in Trial (%) |
|||||||
| 0 – 52 | 196 | 35 (18) | 0.55 | 6,100 | 1,092 (18) | <0.01 | |
| 53 – 123 | 189 | 29 (15) | 15,783 | 2,564 (16) | |||
| ≥124 | 188 | 26 (14) | 65,339 | 7,997 (12) | |||
| Location (%) | |||||||
| U.S. Only | 97 | 12 (12) | 0.52 | 13,396 | 1,859 (14) | 0.04 | |
| U.S. & Non-U.S. Countries | 38 | 5 (13) | 13,281 | 1,701 (13) | |||
| Non-U.S. Only | 438 | 73 (17) | 60,545 | 8,093 (13) | |||
| Therapeutic Intervention (%) | |||||||
| Immunosuppression | 386 | 72 (19) | <0.01 | 68,380 | 10,270 (15) | <0.01 | |
| Other | 187 | 18 (10) | 18,842 | 1,383 (7) | |||
| Journal type | 0.07 | <0.01 | |||||
| Highest impact | 212 | 41 (19) | 42,935 | 6,893 (16) | |||
| Other | 361 | 49 (14) | 44,287 | 4,760 (11) | |||