Conceptual framework demonstrating how cirrhosis-related complications, underlying psychosocial/behavioral issues, and aging contribute to increased informal caregiver burden. Abbreviations: GI, gastrointestinal; HRS, hepatorenal syndrome; HPS, hepatopulmonary syndrome; COPD, chronic obstructive pulmonary disease; CHF, congestive heart failure; DM, diabetes mellitus; CVA, cerebrovascular accident; CAD, coronary artery disease; MI, myocardial infarction, ADL, activity of daily living; IADL, instrumental activity of daily living, IDU; intravenous drug use.