Figure 3.

Relationship between percent weight loss and the change in insulin sensitivity, assessed as the relative increase in insulin-mediated glucose disposal (% change in glucose infusion rate [GIR] in µmol/kg fat-free mass per min) during a hyperinsulinemic-euglycemic clamp procedure (insulin infusion rate of 40–50 mU/m² body surface area per minute) in subjects who had RYGB (white triangles), LAGB/gastroplasty (grey circles) or BPD (black squares) surgeries. Each data point represents the average change insulin sensitivity at a specific average percent weight loss within a study, calculated by using group mean values from published studies that reported adequate data to make these calculations.^{50,51,91,112,113,128–136} The linear regression lines for RYGB (dashed black) and BPD (continuous black) are shown.