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. Author manuscript; available in PMC: 2013 Aug 21.
Published in final edited form as: Biochemistry. 2012 Aug 6;51(33):6499–6510. doi: 10.1021/bi300620c

Figure 8.

Figure 8

A comparison of the canonical molecular motions described for the N-lobe core β-sheet in PKA between the open and closed conformations, with the motion in RSK2 on going from the AMP-PNP32 to the SL0101-bound state, described in this paper. The proteins are superposed on the C-lobe, which is shown as solid surface; the core five-stranded β-sheet on the N-lobe is shown as a cartoon.

(A) A comparison between the AMP-PNP-bound structures of PKA (blue) and RSK2 (cyan);

(B) A comparison of PKA structures with AMP-PNP (blue) and in nucleotide-free state (yellow)64;

(C) A comparison of mRSK2NTKD with AMP-PNP (blue) and with SL0101 (red)