Table 1. TCR-induced expression of different genes in P14 wild-type and PKD2-null (PKD2−/−) T-cells.
Expression of selected genes (from microarray analysis) presented as fold change (as unlogged value) of TCR-triggered samples relative to untreated samples in both P14 wild-type and PKD2-null (PKD2−/−) cells.
| Gene title | Gene symbol | P14 fold change | P14×PKD2−/− fold change |
|---|---|---|---|
| Interleukin 7 receptor | Il7r | −5.00 | −5.88 |
| Krüppel-like factor 2 (lung) | Klf2 | −5.14 | −5.03 |
| Selectin, lymphocyte | Sell | −2.33 | −2.78 |
| Chemokine (C-C motif) receptor 7 | Ccr7 | −2.33 | −2.33 |
| Nuclear receptor subfamily 4, group A, member 1 | Nr4a1 | 6.99 | 7.81 |
| Nuclear receptor subfamily 4, group A, member 2 | Nr4a2 | 9.61 | 9.23 |
| Nuclear receptor subfamily 4, group A, member 3 | Nr4a3 | 8.84 | 6.72 |
| IL-2 | Il2 | 111.99 | 56.62 |
| IL-2 receptor, α chain | Il2ra | 21.95 | 14.23 |
| IL-3 | Il3 | 6.96 | 1.3 |
| IL-6 | Il6 | 2.83 | 1.58 |
| IFN-γ | Ifng | 42.63 | 12.7 |
| Chemokine (C-C motif) ligand 3 | Ccl3 | 133.05 | 36.56 |
| Chemokine (C-C motif) ligand 4 | Ccl4 | 80.72 | 44.55 |
| Chemokine (C-X-C motif) ligand 10 | Cxcl10 | 30.9 | 16.21 |
| Chemokine (C motif) ligand 1 | Xcl1 | 572.12 | 440.68 |
| Chemokine (C-X-C motif) ligand 9 | Cxcl9 | 6.74 | 5.46 |
| Chemokine (C-X-C motif) ligand 1 | Cxcl1 | 6.52 | 2.89 |
| Chemokine (C-X-C motif) ligand 2 | Cxcl2 | 2.7 | 1.38 |
| Chemokine (C-X-C motif) receptor 3 | Cxcr3 | 2.52 | 1.78 |
| Chemokine (C-X-C motif) receptor 6 | Cxcr6 | 2.25 | 2.72 |
| TNF | Tnf | 20.52 | 21.94 |
| TNF (ligand) superfamily, member 11 | Tnfsf11 | 20.28 | 5.12 |
| Lymphotoxin A | Lta | 11.93 | 14.43 |
| Leukaemia inhibitory factor | Lif | 20.78 | 6.36 |
| CD69 antigen | Cd69 | 4.74 | 5.18 |
| B-cell leukaemia/lymphoma 2 | Bcl2 | 2.44 | 2.35 |
| B-cell leukaemia/lymphoma 2-related protein A1a | Bcl2a1a | 6.65 | 4.08 |
| Myelocytomatosis oncogene | Myc | 16.2 | 11.37 |
| Fas ligand (TNF superfamily, member 6) | Fasl | 2.21 | 3.05 |
| Cytotoxic and regulatory T-cell molecule | Crtam | 81.16 | 52.38 |
| T-box 21 | Tbx21 | 48.9 | 35.17 |
| Eomesodermin homologue (Xenopus laevis) | Eomes | 2.19 | 2 |
| Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | Nfatc1 | 6.38 | 7.02 |